October 28, 2015PLoS ONEOpen Access

Congestive Heart Failure Leads to Prolongation of the PR Interval and Atrioventricular Junction Enlargement and Ion Channel Remodelling in the Rabbit

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Population

New Zealand rabbits

Design

Preclinical

Authors

TNTheodora NikolaidouUniversity of Hull XCXue CaiPeking University RSRobert S. StephensonUniversity of Liverpool

Discussion

Member takes

Implication

HF-induced AVJ remodeling may underlie PR prolongation; hypothesis-generating in rabbits, translation to humans remains open.

Structured PICO

Population

New Zealand rabbits

Intervention

Induction of heart failure via disruption of the aortic valve and banding of the abdominal aorta (volume and pressure overload)

Outcome

Anatomical and ion channel remodelling in the atrioventricular junction (AVJ)surrogate

In a rabbit model, heart failure induces significant anatomical enlargement and ion channel remodeling in the atrioventricular junction, leading to PR interval prolongation.

Cite This Study

Nikolaidou et al. (2015) studied this question.

synapsesocial.com/papers/6a0ff3702badbc352aff0837 https://doi.org/10.1371/journal.pone.0141452

Topics

Heart failure Echocardiography HFrEF treatment

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Congestive Heart Failure Leads to Prolongation of the PR Interval and Atrioventricular Junction Enlargement and Ion Channel Remodelling in the Rabbit

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Congestive Heart Failure Leads to Prolongation of the PR Interval and Atrioventricular Junction Enlargement and Ion Channel Remodelling in the Rabbit

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider