February 7, 2006CirculationOpen Access

Larger Cell Size in Rabbits With Heart Failure Increases Myocardial Conduction Velocity and QRS Duration

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Population

Rabbit model of moderate heart failure induced by pressure-volume overload, and computer simulations

Comparison

Heart failure induced by pressure-volume overload vs Control rabbits

Design

Preclinical

Authors

RWRob F. WiegerinckHospital de Sant Pau AVArie O. VerkerkElectrophysiology CBCharly BeltermanUniversité de Bordeaux

Discussion

Member takes

Implication

Does not support slowed conduction as cause of QRS prolongation in HF; hypothesis-generating for hypertrophy mechanisms in translational models.

Structured PICO

Population

Rabbit model of moderate heart failure induced by pressure-volume overload, and computer simulations (Luo-Rudy dynamic model)

Intervention

Heart failure induced by pressure-volume overload

Comparator

Control rabbits

Outcome

QRS duration and conduction velocity (longitudinal, transversal, transmural)surrogate

In a rabbit model of heart failure, prolonged QRS duration results from a hypertrophied left ventricle and increased myocyte size rather than decreased conduction velocity.

Cite This Study

Wiegerinck et al. (2006) studied this question.

synapsesocial.com/papers/6a6fbd6ee5469ee92be097a8 https://doi.org/10.1161/circulationaha.105.565804

Topics

Heart failure HFrEF treatment

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Implication

Does not support slowed conduction as cause of QRS prolongation in HF; hypothesis-generating for hypertrophy mechanisms in translational models.

Larger Cell Size in Rabbits With Heart Failure Increases Myocardial Conduction Velocity and QRS Duration

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Larger Cell Size in Rabbits With Heart Failure Increases Myocardial Conduction Velocity and QRS Duration

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider