Key result
Calcium concentration increased characteristic frequencies b and c by 140% and 44%, respectively (P<0.01), whereas sarcomere length had no effect on these frequencies (P>0.6).
p-value: p=<0.01
Calcium activation modulates force development in rat myocardium via graded effects on cross-bridge kinetics, while sarcomere length effects are mediated mainly by cross-bridge recruitment.
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These in vitro mechanics findings leave open translation to intact myocardium; in vivo validation required before clinical consideration.
Wannenburg et al. (2000) studied Chemically permeabilized rat cardiac trabeculae (n=12). Calcium concentration and sarcomere length was evaluated on Cross-bridge kinetics (characteristic frequencies b and c) (p=<0.01). Calcium concentration increased characteristic frequencies b and c by 140% and 44%, respectively (P<0.01), whereas sarcomere length had no effect on these frequencies (P>0.6).
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