Population
24 cardiac trabeculae isolated from right ventricles of mice (CF-1 males, 25-30 g)
Design
Preclinical
Authors
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Biphasic force-frequency in mouse trabeculae warrants caution extrapolating rat Ca2+ data; extends prior observations but leaves translational relevance open.
In mouse cardiac trabeculae, force generation exhibits a biphasic relationship with stimulation frequency, suggesting a lower capacity of the SR for buffering Ca2+ compared to rats.
Stuyvers et al. (2002) studied this question.
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