February 20, 2008Progress in Biophysics and Molecular BiologyOpen Access

Sarcomere mechanics in uniform and non-uniform cardiac muscle: A link between pump function and arrhythmias

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Population

Rat cardiac trabeculae (intact and skinned) and mathematical kinetic models of twitch-stress

Design

Preclinical

Authors

HKHenk E.D.J. ter KeursUniversity of Calgary TSTsuyoshi ShinozakiTohoku Gakuin University YZYing Ming ZhangDalian Ocean University

Discussion

Member takes

Implication

May explain Starling's law and arrhythmogenic Ca2+ waves; leaves open translation to human myocardium and therapies.

Structured PICO

Population

Rat cardiac trabeculae (intact and skinned) and mathematical kinetic models of twitch-stress

Intervention

Varied sarcomere length (SL) and calcium concentrations, rapid stress changes, and stretch/release cycles

Outcome

Stress-sarcomere length-calcium relationship (sigma-SL-CaR) and occurrence of intracellular calcium transients/wavessurrogate

Force feedback to calcium binding by Troponin-C explains Starling's Law in uniform myocardium and the initiation of arrhythmogenic calcium waves in non-uniform myocardium.

Cite This Study

Keurs et al. (2008) studied this question.

synapsesocial.com/papers/6a83f379ab0020f36262dbf0 https://doi.org/10.1016/j.pbiomolbio.2008.02.013

View Full Paper

Ask AI

Bookmark

Sarcomere mechanics in uniform and non-uniform cardiac muscle: A link between pump function and arrhythmias

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Sarcomere mechanics in uniform and non-uniform cardiac muscle: A link between pump function and arrhythmias

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider