October 1, 2006Annals of the New York Academy of Sciences

Role of Sarcomere Mechanics and Ca²⁺ Overload in Ca²⁺ Waves and Arrhythmias in Rat Cardiac Muscle

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Population

Rat cardiac muscle (trabeculae)

Comparison

Application of a small jet of Hepes solution… vs HC vs HC+BDM, and unstretched vs stretched…

Design

Preclinical

Authors

HKHenk E.D.J. ter KeursUniversity of Calgary YWYuji WakayamaTohoku University YSYoshinao SugaiTohoku University

Discussion

Member takes

Implication

May inform diastolic stretch mechanisms in Ca2+-triggered arrhythmias; leaves open translation to human myocardium or clinical practice.

Structured PICO

Population

Rat cardiac muscle (trabeculae)

Intervention

Application of a small jet of Hepes solution with 10 mM extracellular Ca2+ (HC) or HC with butanedione monoxime (BDM) to weaken a muscle segment, followed by electrical stimuli and small exponential stretches

Comparator

HC vs HC+BDM, and unstretched vs stretched conditions

Outcome

Initiation and propagation velocity of Ca2+ waves, and force of triggered propagatory contraction (TPC)surrogate

In rat cardiac muscle, rapid sarcomere shortening during relaxation contributes to arrhythmogenic Ca2+ waves, which are further potentiated by sarcoplasmic reticulum Ca2+ overload.

Cite This Study

Keurs et al. (2006) studied this question.

synapsesocial.com/papers/6a80b983ea50fa4f0792a52a https://doi.org/10.1196/annals.1380.020

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Role of Sarcomere Mechanics and Ca²⁺ Overload in Ca²⁺ Waves and Arrhythmias in Rat Cardiac Muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Role of Sarcomere Mechanics and Ca²⁺ Overload in Ca²⁺ Waves and Arrhythmias in Rat Cardiac Muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider