Population
Rat cardiac trabeculae
Comparison
Creation of mechanical discontinuity/nonuniformit… vs Restoration of muscle uniformity by turning the…
Design
Preclinical
Authors
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May initiate arrhythmias via myofilament Ca²⁺ waves in nonuniform myocardium; leaves open clinical relevance and therapeutic targeting.
Nonuniform contraction in cardiac muscle can initiate arrhythmogenic Ca2+ waves, suggesting that Ca2+ dissociated from myofilaments plays a key role in arrhythmogenesis.
Keurs et al. (2005) studied this question.
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