Key result
In isolated rat cardiac muscle, spontaneous contractions moved at a constant rate that increased from 0.1 to 15 mm/s with stimulation and calcium loading.
This preclinical study demonstrates that the rate of spontaneous contractions in rat cardiac muscle under calcium loading can be accurately predicted by the calcium-induced calcium release hypothesis.
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No immediate clinical implications; supports calcium-induced calcium release hypothesis in isolated rat myocardium.
Keurs et al. (1988) studied this question. Calcium loading and stimulation was evaluated on Spontaneous contraction rate (Vsc). In isolated rat cardiac muscle, spontaneous contractions moved at a constant rate that increased from 0.1 to 15 mm/s with stimulation and calcium loading.
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