Key result
Neither model compliance nor fluid rheology significantly affected the slopes of the correlations between intimal thickness and normalized shear rate measures in an aortic bifurcation model.
Population
Replicated minimally diseased human aortic bifurcation in rigid and compliant flow-through casts
Comparison
Compliant cast and non-Newtonian fluid rheology vs Rigid cast and Newtonian fluid rheology
Design
Preclinical
Authors
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Compliant aortic models with non-Newtonian fluid feasible; leaves open translation to in vivo wall shear stress.
In an in vitro model of a human aortic bifurcation, neither arterial compliance nor non-Newtonian fluid rheology significantly affected the correlation between intimal thickness and wall shear rate.
Friedman et al. (1992) studied Minimally diseased human aortic bifurcation. Compliant cast and non-Newtonian fluid rheology vs. Rigid cast and Newtonian fluid was evaluated on Correlation between intimal thickness and normalized shear rate measures. Neither model compliance nor fluid rheology significantly affected the slopes of the correlations between intimal thickness and normalized shear rate measures in an aortic bifurcation model.
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