Key result
Combined aerobic exercise and attentional bias modification improved executive function and psychiatric symptoms compared to control (p < .05, η2 = .08-.28) in male patients with MUD.
Why the study?
It remained unclear which individual or combined strategies are most beneficial for methamphetamine use disorders.
Does aerobic exercise combined with attentional bias modification improve heart rate variability, executive function, and cardiorespiratory fitness in male patients with methamphetamine use disorder?
RCT (n=100)
randomly assigned
Does aerobic exercise combined with attentional bias modification improve heart rate variability, executive function, and cardiorespiratory fitness in male patients with methamphetamine use disorder?
Answers are grounded in this paper and cite their sources.
Combination strategies and aerobic exercise alone significantly improved executive function, psychiatric symptoms, and drug craving in male patients with methamphetamine use disorder, with aerobic exercise alone being most effective for heart rate variability and cardiorespiratory fitness.
OBJECTIVE: It remains unclear which individual or combined strategies are most beneficial for methamphetamine use disorders (MUDs). We compared the effects of aerobic exercise, attentional bias modification, and combined intervention on male patients with MUD. METHOD: One hundred male patients with MUD were randomly assigned to combined intervention, aerobic exercise, attentional bias modification, or control groups (25 patients per group). The 8-week intervention protocol included three 60-minute sessions of aerobic exercises per week. Primary outcomes included high- and low-frequency heart rate variability, executive function, and cardiorespiratory fitness measured by customized software, computerized tests, and the Harvard step test, respectively. Secondary outcomes included psychiatric symptoms, drug craving, training acceptability, and persistence. RESULTS: Participant characteristics were matched between groups at baseline. Executive function, heart rate variability, cardiorespiratory fitness, drug craving, and most psychiatric symptoms had significant time-group interactions at posttest (p < .05, η2 = .08-.28). Compared with the attentional bias modification and control groups, the combined intervention and aerobic exercise groups improved significantly in executive function, heart rate variability, cardiorespiratory fitness, and most secondary outcomes. In addition, high-frequency heart rate variability and cardiorespiratory fitness in the aerobic exercise group were significantly higher than those in the combined intervention group. CONCLUSIONS: Combination strategies showed comparable efficacy to aerobic exercise alone in improving executive function, psychiatric symptoms, and drug craving and significantly exceeded other conditions. For heart rate variability and cardiorespiratory fitness, aerobic exercise alone was the most effective. For acceptability and persistence, combination strategies were preferred over single-domain training and health education intervention.
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Liu et al. (2024) conducted an RCT in Methamphetamine use disorder (n=100). Aerobic exercise combined with attentional bias modification vs. Aerobic exercise alone, attentional bias modification alone, or control was evaluated on High- and low-frequency heart rate variability, executive function, and cardiorespiratory fitness (η2 = .08-.28, p=< .05). Combined aerobic exercise and attentional bias modification improved executive function and psychiatric symptoms compared to control (p < .05, η2 = .08-.28) in male patients with MUD.
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