Key result
This article provides background information on the ACTN3 polymorphism and its link to muscle performance to support a classroom laboratory module on genetics and physiology.
Why the study?
To summarize background information needed for instructors to implement a series of laboratory modules examining the implications of ACTN3 genetic testing on sports training and performance.
Key points are not available for this paper at this time.
Laboratory modules enable student exploration of ACTN3 variants and society; leaves open broader curricular adoption.
A common polymorphism in the alpha-actinin-3 (ACTN3) gene results in the lack of ACTN3 protein expression in fast twitch muscle fibers in ~16% of the human population (1). This genetic change has been linked with muscle performance in humans (2) but does not cause any known muscle disease (1). We have developed a series of laboratory modules that provide an authentic classroom research experience and which address the connection between science and society by examining the implications of ACTN3 genetic testing to improve sports training and performance. This article accompanies the lesson "The ACTN3 Polymorphism: Applications in Genetics and Physiology Teaching Laboratories," and summarizes background information that an instructor would need to implement the project in class.
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Somers et al. (2019) studied this question. This article provides background information on the ACTN3 polymorphism and its link to muscle performance to support a classroom laboratory module on genetics and physiology.
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