Key result
The ACTN3 R577X polymorphism is associated with athletic performance, with RR/RX genotypes favoring sprint/power and high-load training, and the XX genotype potentially favoring endurance.
Population
Athletes and the general population
Design
Review
Authors
Loading...
ACTN3 genotyping should not yet guide training selection; leaves open personalized exercise prescriptions.
The ACTN3 R577X polymorphism is conclusively related to sports performance and muscle phenotypes, suggesting genetic information could be used to predict training responses and optimize physical training.
Kikuchi et al. (2015) conducted a review in Athletic performance and muscle phenotypes. ACTN3 R577X polymorphism was evaluated. The ACTN3 R577X polymorphism is associated with athletic performance, with RR/RX genotypes favoring sprint/power and high-load training, and the XX genotype potentially favoring endurance.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: