What question did this study set out to answer?

Investigate how intravenous D-fructose administration influences liver adenine nucleotide levels, purine breakdown products, and hepatic protein synthesis.

September 20, 1968Science

Liver Adenine Nucleotides: Fructose-Induced Depletion and Its Effect on Protein Synthesis

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Authors

PMPekka H. MäenpääTampere University KRKari O. RaivioResearch Council of Finland MKMartti KekomäkiUniversity of Helsinki

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Implication

Laboratory experiment demonstrates rapid liver ATP depletion and inhibited protein synthesis following intravenous fructose in rats, indicating acute disruption of hepatic energy metabolism.

Key Points

Investigate how intravenous D-fructose administration influences liver adenine nucleotide levels, purine breakdown products, and hepatic protein synthesis.
Administered intravenous D-fructose to rats.
Measured hepatic adenosine triphosphate and inorganic phosphate along with plasma uric acid and allantoin concentrations.
Quantified protein synthesis by measuring the hepatic incorporation rate of DL-leucine-1-(14)C.
Intravenous D-fructose rapidly depleted liver adenosine triphosphate (ATP) and inorganic phosphate.
Hepatic nucleotide depletion was followed by marked elevations of uric acid and allantoin in plasma.
Incorporation of DL-leucine-1-(14)C into liver protein was almost completely inhibited concomitantly with ATP loss.

Cite This Study

Mäenpää et al. (1968) studied this question.

synapsesocial.com/papers/6a6bbcafd1b337d10db398dd https://doi.org/10.1126/science.161.3847.1253

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Implication

Laboratory experiment demonstrates rapid liver ATP depletion and inhibited protein synthesis following intravenous fructose in rats, indicating acute disruption of hepatic energy metabolism.

Liver Adenine Nucleotides: Fructose-Induced Depletion and Its Effect on Protein Synthesis

Discussion

Member takes

Implication

Key Points

Cite This Study

Liver Adenine Nucleotides: Fructose-Induced Depletion and Its Effect on Protein Synthesis

Discussion

Member takes

Implication

Key Points

Cite This Study

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