Key result
A single 150 mg oral dose of pregabalin attenuated the pressor response to tracheal intubation in adults undergoing off-pump CABG, but had no effect on perioperative opioid consumption.
Why the study?
Does a single preoperative dose of pregabalin 150 mg attenuate the hemodynamic stress response to intubation and reduce opioid requirements in adults undergoing off-pump CABG?
RCT (n=60)
Double-blind
parallel assignment
No
Does a single preoperative dose of pregabalin 150 mg attenuate the hemodynamic stress response to intubation and reduce opioid requirements in adults undergoing off-pump CABG?
Preemptive pregabalin 150 mg successfully attenuates the hemodynamic stress response to intubation during off-pump CABG but does not provide an opioid-sparing effect.
Single-dose pregabalin attenuates intubation hemodynamics and spares fentanyl in OPCAB; extends preemptive analgesia data in cardiac anesthesia.
The clinical study was designed to evaluate and compare single preoperative dose of pregabalin to a placebo regarding hemodynamic responses to laryngoscopy and endotracheal intubation, to assess perioperative fentanyl requirement and any side-effects. It was a randomized, double-blind, placebo-controlled, parallel assignment, efficacy study. The study was done at a tertiary university hospital. This study was a comparison between two groups of 30 adult patients scheduled for elective off pump coronary artery bypass surgery. In the control group, the patients were given placebo capsules, and in the pregabalin group, the patients were given pregabalin 150 mg capsule orally 1 h before surgery. The patients were compared for hemodynamic changes before the start of the surgery, after induction, 1, 3, and 5 min after intubation. Additionally, fentanyl requirement during surgery and the first postoperative day was also compared. The present study shows that a single oral dose of 150 mg pregabalin given 1 h before surgery attenuated the pressor response to tracheal intubation in adults, but the drug did not show any effect on perioperative opioid consumption and was devoid of side-effects in the given dose.
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Karthekeyan et al. (2012) conducted an RCT in Off-pump coronary artery bypass grafting (n=60). Pregabalin vs. Placebo was evaluated on Hemodynamic responses to laryngoscopy and endotracheal intubation, and perioperative fentanyl requirement. A single 150 mg oral dose of pregabalin attenuated the pressor response to tracheal intubation in adults undergoing off-pump CABG, but had no effect on perioperative opioid consumption.
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