Key result
In GH4C1 rat pituitary cells, 1,25-(OH)2D3 enhanced membrane calcium transport by modulating voltage-operated Ca2+ channels (up to 90% enhancement) and activating Na+/Ca2+ exchange (up to 54%).
Population
GH4C1 rat pituitary cells
Comparison
1,25-dihydroxycholecalciferol vs Control cells
Design
Preclinical
Authors
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Extends mechanistic insight into vitamin D effects on pituitary Ca2+ signaling; leaves open human translational relevance.
1,25-dihydroxycholecalciferol enhances membrane calcium transport in GH4C1 cells by modulating voltage-operated Ca2+ channels and activating Na+/Ca2+ exchange via mechanisms requiring new protein synthesis.
Törnquist et al. (1989) studied GH4C1 rat pituitary cells. 1,25-dihydroxycholecalciferol [1,25-(OH)2D3] vs. control cells was evaluated on 45Ca2+ uptake upon depolarization and Na+/Ca2+ exchange. In GH4C1 rat pituitary cells, 1,25-(OH)2D3 enhanced membrane calcium transport by modulating voltage-operated Ca2+ channels (up to 90% enhancement) and activating Na+/Ca2+ exchange (up to 54%).
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