Key result
Epinephrine, ADP, and collagen liberate collagenase from human platelets during an early phase of platelet aggregation, which can destroy the platelet-aggregating activity of collagen.
Population
Human platelets from normal volunteers
Comparison
Exposure to aggregating agents vs Control
Design
Preclinical
Authors
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May modulate early platelet aggregation; leaves open its role in thrombosis or hemostasis.
Human platelets contain collagenase that is released during early aggregation and can destroy the platelet-aggregating activity of collagen, suggesting a negative feedback mechanism limiting thrombus formation.
Chesney et al. (1974) studied Normal human platelets. Platelet aggregating agents (ADP, epinephrine, collagen) vs. Control (stirring without aggregating agents) was evaluated on Release of collagenase activity measured by hydrolysis of [14C]glycine-labeled collagen fibrils. Epinephrine, ADP, and collagen liberate collagenase from human platelets during an early phase of platelet aggregation, which can destroy the platelet-aggregating activity of collagen.
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