Why the study?
Do protease inhibitors inhibit human platelet aggregation and serotonin release?
Do protease inhibitors inhibit human platelet aggregation and serotonin release?
Protease inhibitors suppress platelet aggregation and serotonin release, suggesting that platelet receptor activation involves a precursor serine protease that activates phospholipase.
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Findings in animal platelets; leaves open serine protease role in human platelet activation and thrombosis.
Aoki et al. (1978) studied this question.
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