Key result
Rat conduit pulmonary artery myocytes exhibit two distinct voltage-gated K+ currents (IKv1 and IKv2), whereas resistance arteries uniformly demonstrate a third distinct type (IKvR).
Population
Rat conduit and resistance pulmonary artery myocytes (PAMs)
Design
Preclinical
Authors
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Characterizes distinct Kv current properties in rat conduit vs resistance PAMs; leaves open relevance to human pulmonary vascular tone and disease.
Rat conduit and resistance pulmonary arteries possess electrophysiologically distinct smooth muscle cell subtypes based on their voltage-gated K+ current profiles.
Sv et al. (2002) studied this question. Patch clamp technique on rat conduit and resistance pulmonary artery myocytes was evaluated on Electrophysiological and pharmacological properties of voltage-gated K+ (Kv) current. Rat conduit pulmonary artery myocytes exhibit two distinct voltage-gated K+ currents (IKv1 and IKv2), whereas resistance arteries uniformly demonstrate a third distinct type (IKvR).
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