Key result
Coexpression of Kv2.1 with Kv5.1 or Kv6.1 in Xenopus oocytes modulated channel gating, with Kv5.1 accelerating inactivation and Kv6.1 shifting steady-state activation.
Kv5.1 and Kv6.1 function as regulatory alpha-subunits that modulate Kv2.1 channel gating in distinct, physiologically relevant ways.
No takes yet. Share an insight, caveat, or question.
Kv5.1/Kv6.1 heteromers alter Kv2.1 gating in oocytes; leaves open roles in native cardiac repolarization.
Kramer et al. (1998) studied this question. Coexpression of Kv2.1 with Kv5.1 or Kv6.1 alpha-subunits was evaluated on Channel gating (inactivation and activation rates). Coexpression of Kv2.1 with Kv5.1 or Kv6.1 in Xenopus oocytes modulated channel gating, with Kv5.1 accelerating inactivation and Kv6.1 shifting steady-state activation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: