November 1, 1999PLANT PHYSIOLOGYOpen Access

Evaluation of Functional Interaction between K+Channel α- and β-Subunits and Putative Inactivation Gating by Co-Expression in Xenopus laevisOocytes

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Population

Xenopus laevis oocytes

Comparison

Co-expression of KAT1 and KAB1, or co-expression… vs Expression of KAT1 alone

Design

Preclinical

Authors

XZXiao ZhangNingxia Medical University JMJiong Ma GBGerald A. BerkowitzUniversity of Connecticut

Discussion

Member takes

Implication

KAB1 may act as K+ channel beta-subunit; leaves open cardiac excitability effects in vivo.

Structured PICO

Population

Xenopus laevis oocytes

Intervention

Co-expression of KAT1 (plant K+ channel alpha-subunit) and KAB1 (putative homolog of animal K+ channel beta-subunits), or co-expression of KAT1 with hKv1.4

Comparator

Expression of KAT1 alone

Outcome

Electrophysiological parameters of K+ currents (gating kinetics, total current, voltage-dependent inactivation)surrogate

Co-expression of KAT1 and KAB1 in Xenopus oocytes enhances total K+ current, suggesting KAB1 acts as a beta-subunit that stabilizes the channel protein complex.

Cite This Study

Zhang et al. (1999) studied this question.

synapsesocial.com/papers/6a8d20960bd5a3045f314d24 https://doi.org/10.1104/pp.121.3.995

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Evaluation of Functional Interaction between K+Channel α- and β-Subunits and Putative Inactivation Gating by Co-Expression in Xenopus laevisOocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Evaluation of Functional Interaction between K+Channel α- and β-Subunits and Putative Inactivation Gating by Co-Expression in Xenopus laevisOocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider