Key result
Iberiotoxin (100 nM) increased the action potential frequency from 0.11 to 0.29 Hz and altered the configuration by increasing duration and peak amplitude in guinea pig urinary bladder smooth muscle.
Why the study?
Does blocking Ca(2+)-activated K+ channels with iberiotoxin alter action potential repolarization in guinea pig urinary bladder smooth muscle?
Population
Guinea pig urinary bladder smooth muscle
Comparison
Iberiotoxin (100 nM) and tetraethylammonium vs Baseline/control conditions without channel…
Design
Preclinical
Authors
Loading...
BK channels may modulate bladder myocyte excitability; leaves open therapeutic targeting in human detrusor disorders.
Does blocking Ca(2+)-activated K+ channels with iberiotoxin alter action potential repolarization in guinea pig urinary bladder smooth muscle?
Absolute Event Rate: 0.29% vs 0.11%
Ca(2+)-activated K+ channels play a significant role in the repolarization of the action potential and maintenance of resting membrane potential in urinary bladder smooth muscle.
Heppner et al. (1997) studied Guinea pig urinary bladder smooth muscle. Iberiotoxin was evaluated on Action potential frequency. Iberiotoxin (100 nM) increased the action potential frequency from 0.11 to 0.29 Hz and altered the configuration by increasing duration and peak amplitude in guinea pig urinary bladder smooth muscle.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: