November 11, 2001Acta Physiologica Scandinavica
Effects of different types of K+ channel modulators on the spontaneous myogenic contraction of guinea‐pig urinary bladder smooth muscle
Population
Guinea-pig urinary bladder smooth muscle (UBSM)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Should not change clinical practice for bladder disorders; hypothesis-generating for BK/SK modulation in smooth muscle.
Structured PICO
P
Population
Guinea-pig urinary bladder smooth muscle (UBSM)
I
Intervention
Various K+ channel modulators (including iberiotoxin, NS-1619, apamin, 4-aminopyridine, E-4031, glibenclamide, Ba2+)
O
Outcome
Spontaneous rhythmic contractile activity (amplitude and frequency)surrogate
BK and SK channels act as negative feedback elements to limit extracellular Ca2+ influx-mediated contraction in guinea-pig urinary bladder smooth muscle.
Cite This Study
Imai et al. (2001) studied this question.