Population
Detrusor and portal vein strips from guinea pigs
Design
Preclinical
Authors
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Supports tissue-selective K+ modulator exploration; leaves open translation from animal tissues to clinical use.
The study demonstrates functional dissimilarities in the response of vascular and nonvascular smooth muscle to K+ channel modulators, suggesting potential for tissue-selective drug design.
Zografos et al. (2008) studied this question.
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