May 1, 1991British Journal of PharmacologyOpen Access

Comparison of the effects of the K+‐channel openers cromakalim and minoxidil sulphate on vascular smooth muscle

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Population

Isolated blood vessel preparations

Comparison

Cromakalim and minoxidil sulphate vs Comparison between the two agents and effects of…

Design

Preclinical

Authors

AWAlan D. WickendenTri-Institutional Therapeutics Discovery Institute SGS. GrimwoodUniversity of Turku TGT.L. GrantAstraZeneca (United Kingdom)

Discussion

Member takes

Implication

May indicate vessel-specific KATP subtypes in animals; hypothesis-generating and should not change clinical practice.

Structured PICO

Population

Isolated blood vessel preparations (guinea-pig portal vein, rat aorta, rat portal vein, rat mesenteric artery, rabbit aorta)

Intervention

Cromakalim and minoxidil sulphate (potassium channel openers)

Comparator

Comparison between the two agents and effects of various antagonists (charybdotoxin, noxiustoxin, rubidium, glibenclamide)

Outcome

Inhibition of spontaneous mechanical activity and relaxation of noradrenaline precontracted vesselssurrogate

Cromakalim and minoxidil sulphate exhibit differential relaxant effects across various isolated blood vessels, suggesting the involvement of different subtypes of ATP-sensitive potassium channels.

Cite This Study

Wickenden et al. (1991) studied this question.

synapsesocial.com/papers/6a85380fca39fc72e8c2a5b2 https://doi.org/10.1111/j.1476-5381.1991.tb12315.x

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Comparison of the effects of the K+‐channel openers cromakalim and minoxidil sulphate on vascular smooth muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Comparison of the effects of the K+‐channel openers cromakalim and minoxidil sulphate on vascular smooth muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider