June 1, 1990British Journal of PharmacologyOpen Access

Characterization of responses to cromakalim and pinacidil in smooth and cardiac muscle by use of selective antagonists

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Population

Dog isolated coronary artery, guinea-pig thoracic aorta, ileum, and trachea, and rat right atrial and left…

Design

Preclinical

Authors

GMGrant A. McPhersonNipissing University JAJames A. AngusVascular / Pulmonary Vascular

Discussion

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Implication

Indicates vascular selectivity of K+ channel openers in animals; leaves open translation to human vasodilator therapy.

Structured PICO

Population

Dog isolated coronary artery (precontracted with endothelin), guinea-pig thoracic aorta, ileum, and trachea, and rat right atrial and left ventricular strip preparations

Intervention

Cromakalim (0.1-30 microM) and pinacidil (1-30 microM) with antagonists glibenclamide, phentolamine, or alinidine

Outcome

Vasorelaxant responses and force/rate generationsurrogate

Cromakalim and pinacidil activate K+ channels in vascular and non-vascular smooth muscle with little heterogeneity, but have minimal functional effects on cardiac muscle.

Cite This Study

McPherson et al. (1990) studied this question.

synapsesocial.com/papers/6a87e17abc6dec9ec2262dec https://doi.org/10.1111/j.1476-5381.1990.tb15782.x

View Full Paper

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Characterization of responses to cromakalim and pinacidil in smooth and cardiac muscle by use of selective antagonists

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Characterization of responses to cromakalim and pinacidil in smooth and cardiac muscle by use of selective antagonists

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider