Why the study?
Does glibenclamide inhibit the vasorelaxant and hypotensive actions of cromakalim in rats?
Population
Rat isolated thoracic aortic rings, rat isolated portal veins, and conscious rats
Comparison
Cromakalim (in vitro: 3 x 10 to 3 x 10 M; in… vs Cromakalim alone
Design
Preclinical
Authors
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May inform vascular K+ channel pharmacology in animals; leaves open human translation and channel identity.
Does glibenclamide inhibit the vasorelaxant and hypotensive actions of cromakalim in rats?
The vasorelaxant and hypotensive actions of cromakalim involve a K+ channel that is inhibited by glibenclamide, which may be distinct from the ATP-sensitive K+ channel of the pancreatic beta-cell.
Buckingham et al. (1989) studied this question.
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