Population
Rabbit isolated mesenteric artery
Comparison
Sulphonylureas vs Nifedipine (Ca2+ channel blocker)
Design
Preclinical
Authors
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Hypothesis-generating for sulfonylurea effects on vascular tone; leaves open whether ATP-sensitive K+ channels differ from pancreatic beta-cell channels.
Sulphonylureas inhibit vasorelaxation induced by K+ channel activators in vascular smooth muscle, suggesting activation of an ATP-sensitive K+ channel that may differ from pancreatic beta-cells.
Campbell Wilson (1989) studied this question.
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