Key result
Cromakalim caused hyperpolarization, abolished spike activity, increased K+ fluxes, and relaxed guinea-pig bladder smooth muscle via channels similar to delayed rectifier and ATP-dependent K+ channels.
Population
Strips of smooth muscle from the guinea-pig urinary bladder
Design
Preclinical
Authors
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K+ channel blockade may enhance detrusor excitability; hypothesis-generating for underactive bladder, pending in vivo studies.
Cromakalim relaxes guinea-pig bladder smooth muscle by opening potassium channels that share properties with delayed rectifier and ATP-dependent K+ channels.
Fujii et al. (1990) studied this question. Potassium channel blockers and cromakalim was evaluated on Mechanical activity, spontaneous action potentials, K+ fluxes, and membrane potential. Cromakalim caused hyperpolarization, abolished spike activity, increased K+ fluxes, and relaxed guinea-pig bladder smooth muscle via channels similar to delayed rectifier and ATP-dependent K+ channels.
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