Population
Circular muscle strips of the antrum of guinea-pig stomach
Design
Preclinical
Authors
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Cautions against extrapolating cromakalim effects from guinea-pig models to human gastric therapy; leaves open mechanistic dissociation for targeted research.
In guinea-pig gastric antrum, cromakalim inhibits mechanical activity through mechanisms that dissociate from membrane hyperpolarization or slow wave inhibition.
Katayama et al. (1993) studied this question.
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