Population
Rat aorta and portal vein
Comparison
Diazoxide and minoxidil sulphate vs Cromakalim
Design
Preclinical
Authors
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Animal data on vascular K+ modulation require human validation; leaves open therapeutic translation for hypertension.
Diazoxide and minoxidil sulphate act as potassium channel openers in rat vascular smooth muscle, similar to cromakalim, though with some distinct mechanistic differences.
Newgreen et al. (1990) studied this question.
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