July 1, 2000AJP Regulatory Integrative and Comparative PhysiologyOpen Access

Regulation of urinary bladder smooth muscle contractions by ryanodine receptors and BK and SK channels

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Population

Guinea pig urinary bladder smooth muscle (UBSM)

Design

Preclinical

Authors

GHGerald M. HerreraUniversity of Vermont THThomas J. HeppnerUniversity of Vermont MNMark T. NelsonUniversity of Vermont

Discussion

Member takes

Implication

Ion channel modulation of bladder contractility merits human studies; leaves open therapeutic translation in detrusor dysfunction.

Structured PICO

Population

Guinea pig urinary bladder smooth muscle (UBSM)

Intervention

Pharmacological modulation using nisoldipine (100 nM), ryanodine (10 microM), iberiotoxin (100 nM), and apamin (100 nM)

Outcome

Phasic contractions (amplitude, duration, frequency, and integrated force)surrogate

BK and SK channels, along with ryanodine receptors, act as negative feedback regulators of urinary bladder smooth muscle contraction amplitude, duration, and frequency.

Cite This Study

Herrera et al. (2000) studied this question.

synapsesocial.com/papers/6a8040a37a38d5ff71e4554a https://doi.org/10.1152/ajpregu.2000.279.1.r60

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Regulation of urinary bladder smooth muscle contractions by ryanodine receptors and BK and SK channels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Regulation of urinary bladder smooth muscle contractions by ryanodine receptors and BK and SK channels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider