Why the study?
Do potassium channel modulators alter the spontaneous phasic activity of pig urinary bladder smooth muscle?
Do potassium channel modulators alter the spontaneous phasic activity of pig urinary bladder smooth muscle?
Potassium channel modulation, particularly via K(ATP) channels, may offer a unique mechanism for controlling spontaneous myogenic activity associated with hyperexcitability in unstable bladders.
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May support K(ATP) openers for detrusor instability; leaves open translation to human overactive bladder therapy.
Buckner et al. (2002) studied this question.
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