Key result
The GNAS -1211G allele was associated with higher baseline deceleration time and its attenuation after 6 months of exercise training in heart failure patients compared to -1211A homozygotes (P<0.05).
Why the study?
Do ADRB1 and GNAS genetic variants influence the response of left ventricular function and exercise tolerance to a 6-month exercise training program in heart failure patients?
Observational (n=61)
Do ADRB1 and GNAS genetic variants influence the response of left ventricular function and exercise tolerance to a 6-month exercise training program in heart failure patients?
Specific genetic variants in GNAS and ADRB1 are associated with differential improvements in diastolic function and exercise tolerance following a 6-month exercise program in heart failure patients.
ADRB1/GNAS variants may modulate exercise effects on LV function in HF; leaves open clinical utility without prospective validation.
β1-adrenergic receptors (ADRB1) and Gαs proteins (GNAS) play important roles in the regulation of cardiac function. The present study sought to investigate whether ADRB1 Arg389Gly (rs1801253), GNAS -1211 G/A (rs6123837) and GNAS 2291 C/T (rs6026584) variants are associated with left ventricular function and exercise tolerance in heart failure patients. 61 heart failure patients completed a 6-month exercise-training programme. Left ventricular ejection fraction (LVEF), mitral inflow velocities (deceleration time, and E/A ratio) and exercise tolerance (METs) were assessed at baseline and following exercise training. There were no associations between the studied variants and LVEF or E/A ratio measured at baseline and after exercise training. Deceleration time of early mitral flow was higher at baseline in GNAS -1211G allele carriers compared with -1211A allele homozygotes (P<0.05). Exercise training attenuated deceleration time in -1211G allele carriers (P<0.05) but not in -1211A allele homozygotes. Moreover, ADRB1 389Gly homozygotes had a greater training-induced increase in exercise tolerance than 389Arg homozygotes (P=0.04). This study shows that the functional GNAS -1121 G/A polymorphism is associated with diastolic function at baseline and in response to exercise training in heart failure patients. Furthermore, our data suggest that ADRB1 Arg389Gly polymorphism may influence exercise tolerance.
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Alves et al. (2012) conducted an observational in Heart failure (n=61). GNAS -1211 G/A and ADRB1 Arg389Gly variants vs. Alternative genotypes (e.g., -1211A allele homozygotes) was evaluated on Left ventricular function (LVEF, deceleration time, E/A ratio) and exercise tolerance (METs) (p=<0.05). The GNAS -1211G allele was associated with higher baseline deceleration time and its attenuation after 6 months of exercise training in heart failure patients compared to -1211A homozygotes (P<0.05).
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