Key result
31P NMR of frog and toad muscles showed that following a 25 s tetanus, approximately 20% of PCr was hydrolysed and subsequently rebuilt exponentially with a half-time of about 10 minutes.
31P NMR can be used to continuously monitor intracellular concentrations of phosphorus metabolites and pH in living muscle during contraction and recovery.
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Demonstrates 31P NMR feasibility in stimulated muscle; leaves open translation to cardiac metabolism in vivo.
Gadian et al. (1977) studied Living muscles (frog and toad). Electrical stimulation (tetani) vs. Resting muscle (absence of stimulation) was evaluated on Concentrations of phosphorus-containing metabolites (ATP, PCr, Pi, sugar P) and intracellular pH. 31P NMR of frog and toad muscles showed that following a 25 s tetanus, approximately 20% of PCr was hydrolysed and subsequently rebuilt exponentially with a half-time of about 10 minutes.
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