In bull-frog skeletal muscles, tetanic stimulation causes a biphasic increase in inorganic phosphate and an alkaline shift in intracellular pH that correlates with contraction duration.
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Biphasic Pi rise in frog skeletal muscle warrants caution extrapolating to human cardiac energetics; leaves open pH-Pi dynamics in mammalian myocardium.
Kawano et al. (1988) studied this question.
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