June 1, 2004Viral Immunology
Structural Similarities in the Cellular Receptors Used by Adenovirus and Reovirus
Key result
Adenovirus and reovirus share structural similarities in their cellular receptors and attachment proteins, suggesting a conserved mechanism of attachment and an evolutionary relationship.
Population
Adenovirus and reovirus cellular receptors (CAR and JAM1) and attachment proteins (fiber and sigma1)
Design
Review
Authors
Discussion
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Implication
Viruses engage CAR/JAM1 at homodimer interfaces; leaves open whether this motif is shared by other pathogens.
Structured PICO
P
Population
Adenovirus and reovirus cellular receptors (CAR and JAM1) and attachment proteins (fiber and sigma1)
Adenovirus and reovirus share structural similarities in their cellular receptors and attachment proteins, suggesting a conserved evolutionary mechanism of viral attachment.
Cite This Study
Stehle et al. (2004) conducted a review in Adenovirus and reovirus. Adenovirus and reovirus share structural similarities in their cellular receptors and attachment proteins, suggesting a conserved mechanism of attachment and an evolutionary relationship.