Although colorectal cancer continues to be a majorcause of cancer death worldwide, considerable improve-menthasbeenachievedinthelastdecadewiththeadventofnewer chemotherapy agents such as irinotecan and oxali-platin. This advance is most obvious in the treatment ofpatients with metastatic disease, in whom the median sur-vival now exceeds 20 months.
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Ellis et al. (2004) studied this question.