Key result
Based on a review of 3 best evidence papers, NSAIDs following pleurodesis may reduce the effectiveness of the procedure, suggesting they should be used with caution or avoided routinely.
Why the study?
Do non-steroidal anti-inflammatory drugs (NSAIDs) decrease the effect of pleurodesis?
Do non-steroidal anti-inflammatory drugs (NSAIDs) decrease the effect of pleurodesis?
NSAIDs should be used with caution and probably avoided routinely following pleurodesis due to concerns they may reduce its effectiveness.
Supports caution with perioperative NSAIDs after pleurodesis; leaves open need for randomized confirmation of any effect on success.
A best evidence topic in cardiothoracic surgery was written according to a structured protocol. The question addressed was whether non-steroidal anti-inflammatory drugs (NSAIDs) decrease the effect of pleurodesis. Only 17 papers were identified using the search below. Three papers presented the best evidence to answer the clinical question. The author, journal, date and country of publication, patient group studied, study type, relevant outcomes, results, and study weaknesses of the papers are tabulated. We conclude that despite a limited number and type of study, there is some histopathological evidence to support the concern that NSAIDs may reduce effectiveness of pleurodesis. Until further clinical studies with appropriate outcome measures are available, NSAIDs following pleurodesis should be used with caution and probably avoided routinely.
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Hunt et al. (2006) conducted a review in Pleurodesis. Non-steroidal anti-inflammatory drugs (NSAIDs) was evaluated on Effectiveness of pleurodesis. Based on a review of 3 best evidence papers, NSAIDs following pleurodesis may reduce the effectiveness of the procedure, suggesting they should be used with caution or avoided routinely.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: