What question did this study set out to answer?

This research aims to explore the role of endothelin in the increased vasoconstrictor tone observed in hypertensive patients.

February 1, 1999HypertensionOpen Access

Role of Endothelin in the Increased Vascular Tone of Patients With Essential Hypertension

Q: What is the clinical evidence from this study?

Study design: Other. Population: Essential Hypertension. Intervention: Combination of BQ-123 (ETA blocker) and BQ-788 (ETB blocker) vs. BQ-123 alone. Primary outcome: Forearm blood flow (FBF) response (p=0.006).

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Key result

In hypertensive patients, combined ETA and ETB blockade increased forearm blood flow by 63% compared to 33% with ETA blockade alone (P=0.006).

Why the study?

Does intraarterial infusion of endothelin receptor blockers increase forearm blood flow in patients with essential hypertension?

Population

Hypertensive patients and normotensive control subjects

Comparison

Intraarterial infusion of endothelin-A blocker… vs Normotensive control subjects and baseline…

Design

Cross-sectional

Authors

CCCarmine CardilloUniversità Cattolica del Sacro Cuore CKCrescence M. KilcoyneUniversità Cattolica del Sacro Cuore MWMyron A. WaclawiwGeneral / Preventive / Lipids

Discussion

Member takes

Implication

Endothelin may contribute to vasoconstrictor tone in hypertension; leaves open whether receptor antagonists offer therapeutic value.

Key Points

This research aims to explore the role of endothelin in the increased vasoconstrictor tone observed in hypertensive patients.
Measured forearm blood flow responses using strain-gauge plethysmography in hypertensive and normotensive subjects.
Administered endothelin-A receptor antagonist BQ-123 and endothelin-B receptor antagonist BQ-788, both alone and in combination.
Conducted statistical analyses to compare the effects on blood flow between the two groups.
BQ-123 significantly increased forearm blood flow in hypertensive patients by 33% (P<0.001 vs. baseline).
The combination of BQ-123 and BQ-788 produced an even greater increase of 63% (P=0.006 vs. BQ-123 alone).
In normotensive controls, BQ-788 decreased forearm blood flow by 17% (P=0.004 vs. baseline), while it induced transient vasodilation in hypertensive patients (15% after 20 minutes, P<0.001 vs. controls).

Structured PICO

Does intraarterial infusion of endothelin receptor blockers increase forearm blood flow in patients with essential hypertension?

Population

Hypertensive patients and normotensive control subjects evaluated for forearm blood flow responses to endothelin receptor blockers.

Intervention

Intraarterial infusion of endothelin-A blocker (BQ-123) and endothelin-B blocker (BQ-788), separately and in combination

Comparator

Normotensive control subjects and baseline measurements

Outcome

Forearm blood flow (FBF) responses measured by strain-gauge plethysmographysurrogate

Main Result

Absolute Event Rate: 63% vs 33%

p-value: p=0.006

Patients with essential hypertension exhibit increased vascular endothelin activity, and combined ETA/ETB blockade produces greater vasodilation than ETA blockade alone.

Cite This Study

Cardillo et al. (1999) studied Essential Hypertension. Combination of BQ-123 (ETA blocker) and BQ-788 (ETB blocker) vs. BQ-123 alone was evaluated on Forearm blood flow (FBF) response (p=0.006). In hypertensive patients, combined ETA and ETB blockade increased forearm blood flow by 63% compared to 33% with ETA blockade alone (P=0.006).

synapsesocial.com/papers/6a6bef221e51ef7293b3e533 https://doi.org/10.1161/01.hyp.33.2.753

Topics

Hypertension management

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February 1, 1999HypertensionOpen Access

Role of Endothelin in the Increased Vascular Tone of Patients With Essential Hypertension

View Full Paper

Ask AI

Bookmark

Key result

In hypertensive patients, combined ETA and ETB blockade increased forearm blood flow by 63% compared to 33% with ETA blockade alone (P=0.006).

Why the study?

Does intraarterial infusion of endothelin receptor blockers increase forearm blood flow in patients with essential hypertension?

Population

Hypertensive patients and normotensive control subjects

Comparison

Intraarterial infusion of endothelin-A blocker… vs Normotensive control subjects and baseline…

Design

Cross-sectional

Authors

CCCarmine CardilloUniversità Cattolica del Sacro Cuore CKCrescence M. KilcoyneUniversità Cattolica del Sacro Cuore MWMyron A. WaclawiwGeneral / Preventive / Lipids

Discussion

Member takes

Implication

Endothelin may contribute to vasoconstrictor tone in hypertension; leaves open whether receptor antagonists offer therapeutic value.

Key Points

This research aims to explore the role of endothelin in the increased vasoconstrictor tone observed in hypertensive patients.
Measured forearm blood flow responses using strain-gauge plethysmography in hypertensive and normotensive subjects.
Administered endothelin-A receptor antagonist BQ-123 and endothelin-B receptor antagonist BQ-788, both alone and in combination.
Conducted statistical analyses to compare the effects on blood flow between the two groups.
BQ-123 significantly increased forearm blood flow in hypertensive patients by 33% (P<0.001 vs. baseline).
The combination of BQ-123 and BQ-788 produced an even greater increase of 63% (P=0.006 vs. BQ-123 alone).
In normotensive controls, BQ-788 decreased forearm blood flow by 17% (P=0.004 vs. baseline), while it induced transient vasodilation in hypertensive patients (15% after 20 minutes, P<0.001 vs. controls).

Structured PICO

Does intraarterial infusion of endothelin receptor blockers increase forearm blood flow in patients with essential hypertension?

Population

Hypertensive patients and normotensive control subjects evaluated for forearm blood flow responses to endothelin receptor blockers.

Intervention

Intraarterial infusion of endothelin-A blocker (BQ-123) and endothelin-B blocker (BQ-788), separately and in combination

Comparator

Normotensive control subjects and baseline measurements

Outcome

Forearm blood flow (FBF) responses measured by strain-gauge plethysmographysurrogate

Main Result

Absolute Event Rate: 63% vs 33%

p-value: p=0.006

Patients with essential hypertension exhibit increased vascular endothelin activity, and combined ETA/ETB blockade produces greater vasodilation than ETA blockade alone.

Cite This Study

synapsesocial.com/papers/6a6bef221e51ef7293b3e533 https://doi.org/10.1161/01.hyp.33.2.753

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