Key result
Intracerebroventricular angiotensin II infusion significantly impaired cognitive function and increased brain injury in 5XFAD Alzheimer disease mice compared with wild-type mice.
Why the study?
Does intracerebroventricular angiotensin II infusion cause greater cognitive and systemic detrimental effects in a mouse model of Alzheimer disease compared to wild-type mice?
Does intracerebroventricular angiotensin II infusion cause greater cognitive and systemic detrimental effects in a mouse model of Alzheimer disease compared to wild-type mice?
Brain angiotensin II exacerbates cognitive impairment, brain injury, cardiac dysfunction, and sarcopenia in a mouse model of Alzheimer's disease.
No takes yet. Share an insight, caveat, or question.
Central angiotensin II effects on cognition merit human investigation; leaves open clinical translation from this animal model.
Takane et al. (2017) studied Alzheimer disease. Intracerebroventricular angiotensin II infusion vs. Wild-type mice was evaluated on Cognitive function. Intracerebroventricular angiotensin II infusion significantly impaired cognitive function and increased brain injury in 5XFAD Alzheimer disease mice compared with wild-type mice.
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