Key result
Central angiotensin 1-7 infusion improves cognitive function and cerebrovascular reactivity in Alzheimer mice.
Why the study?
The potential of angiotensin-(1-7) to ameliorate cognitive impairment and cerebrovascular reactivity in a mouse model of Alzheimer's disease was investigated.
Does intracerebroventricular infusion of angiotensin-(1-7) improve cognitive impairment and cerebrovascular reactivity in a mouse model of Alzheimer's disease?
Population
5XFAD mice, a model of Alzheimer's disease
Comparison
Intracerebroventricular infusion of vehicle vs angiotensin-(1-7) vs angiotensin-(1-7) + A779
Design
Preclinical study
Follow-up
4 weeks
Authors
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May support Mas receptor agonism in Alzheimer's models; leaves open human translation.
Does intracerebroventricular infusion of angiotensin-(1-7) improve cognitive impairment and cerebrovascular reactivity in a mouse model of Alzheimer's disease?
Intracerebroventricular infusion of angiotensin-(1-7) improves cognitive and cerebrovascular function in a mouse model of Alzheimer's disease via the Mas receptor.
Uekawa et al. (2016) studied Alzheimer's disease (mouse model). Intracerebroventricular infusion of angiotensin-(1-7) vs. Vehicle or angiotensin-(1-7)+A779 was evaluated on Cognitive impairment and cerebrovascular reactivity. Intracerebroventricular infusion of angiotensin-(1-7) significantly ameliorated cognitive impairment and enhanced cerebrovascular reactivity in a mouse model of Alzheimer's disease.
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