Key result
Short-term maturity-onset diabetes was associated with an increased resting heart rate (80 vs 69 beats/min, P<0.01) and impaired cardiovascular reflexes compared to healthy volunteers.
Why the study?
Do short-term maturity-onset diabetics exhibit disturbances in sympathetic and parasympathetic control of cardiac functions compared to healthy volunteers?
Population
15 maturity-onset diabetics with normal sensory tests, positive Achilles tendon jerks, and no signs of…
Comparison
Maturity-onset diabetes (short-term duration) vs Healthy volunteers
Design
Case-control
Authors
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Early vagal neuropathy may occur despite normal sensation in short-term diabetes; leaves open need for prospective autonomic screening studies.
Case-Control (n=34)
Do short-term maturity-onset diabetics exhibit disturbances in sympathetic and parasympathetic control of cardiac functions compared to healthy volunteers?
Absolute Event Rate: 80% vs 69%
p-value: p=<0.01
Short-term maturity-onset diabetics exhibit impaired cardiovascular reflexes indicative of early vagal neuropathy, even when physical working capacity remains normal.
Berglund et al. (1980) conducted a case-control in Short-term maturity-onset diabetes (n=34). Short-term maturity-onset diabetes vs. Healthy volunteers was evaluated on Resting heart rate (beats/min) (p=<0.01). Short-term maturity-onset diabetes was associated with an increased resting heart rate (80 vs 69 beats/min, P<0.01) and impaired cardiovascular reflexes compared to healthy volunteers.
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