What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Type 1 diabetes (n=159). Intervention: Duration of diabetes and blood pressure. Primary outcome: Abnormal cardiovascular reflexes (cardiac autonomic dysfunction) (p=<0.01).

What question did this study set out to answer?

To evaluate cardiac autonomic nerve function using noninvasive reflex testing and identify clinical correlates of autonomic dysfunction in young women with type 1 diabetes.

August 11, 2017American Journal of Noninvasive Cardiology

Abnormalities in Cardiovascular Autonomic Reflexes in Type 1 Diabetes: Clinical Correlates

Q: What are the key findings of this study?

Duration of diabetes (p<0.01) and blood pressure (p<0.001) were the strongest independent predictors of cardiac autonomic dysfunction in young women with type 1 diabetes.

Q: What question did this study set out to answer?

To evaluate cardiac autonomic nerve function using noninvasive reflex testing and identify clinical correlates of autonomic dysfunction in young women with type 1 diabetes.

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Key result

Duration of diabetes (p<0.01) and blood pressure (p<0.001) were the strongest independent predictors of cardiac autonomic dysfunction in young women with type 1 diabetes.

Why the study?

What are the clinical predictors of abnormal cardiovascular autonomic reflexes in young women with type 1 diabetes?

Population

159 women aged 15-40 years with type 1 diabetes

Design

Cross-sectional

Authors

JAJuhani AiraksinenElectrophysiology PSPasi SalmelaOulu University Hospital MLMarkku LinnaluotoOulu University Hospital

Discussion

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Implication

May inform risk stratification by diabetes duration and BP in young T1D women; hypothesis-generating and requires prospective validation.

Key Points

To evaluate cardiac autonomic nerve function using noninvasive reflex testing and identify clinical correlates of autonomic dysfunction in young women with type 1 diabetes.
Assessed cardiac autonomic reflexes—including heart rate variation during deep breathing, heart rate response to standing, and postural blood pressure changes—in 159 women with type 1 diabetes aged 15–40 years.
Identified independent clinical correlates of reflex abnormalities using stepwise multivariable logistic regression analysis.
Abnormal cardiovascular reflexes occurred in 46 women (29%), driven primarily by inadequate heart rate variation during deep breathing (26%, n=42), followed by abnormal response to standing (9%, n=15) and postural hypotension (2%, n=3), with 7% (n=11) demonstrating at least two abnormal tests.
Duration of diabetes was an independent predictor of autonomic dysfunction (p < 0.01), with systolic and diastolic blood pressure showing the strongest associations after duration adjustment (p < 0.001 for both).
Glycohemoglobin, BMI, and insulin dose initially associated with dysfunction (p < 0.05), but only insulin dose remained borderline significant (p = 0.07) after adjusting for systolic blood pressure, while nephropathy, retinopathy, age, and smoking showed no independent effect.

Study Design

Type

Cross-Sectional (n=159)

Structured PICO

What are the clinical predictors of abnormal cardiovascular autonomic reflexes in young women with type 1 diabetes?

Population

159 women aged 15-40 years with type 1 diabetes evaluated for clinical correlates of cardiac autonomic function.

Outcome

Prevalence of abnormal cardiovascular autonomic reflexes and their clinical predictorssurrogate

Main Result

p-value: p=<0.01

In young women with type 1 diabetes, the duration of the disease and blood pressure levels are the strongest predictors of cardiac autonomic dysfunction.

Cite This Study

Airaksinen et al. (2017) conducted a cross-sectional in Type 1 diabetes (n=159). Duration of diabetes and blood pressure was evaluated on Abnormal cardiovascular reflexes (cardiac autonomic dysfunction) (p=<0.01). Duration of diabetes (p<0.01) and blood pressure (p<0.001) were the strongest independent predictors of cardiac autonomic dysfunction in young women with type 1 diabetes.

synapsesocial.com/papers/6a8f89f054e2d1a6b2d7844a https://doi.org/10.1159/000470366

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Abnormalities in Cardiovascular Autonomic Reflexes in Type 1 Diabetes: Clinical Correlates

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Abnormalities in Cardiovascular Autonomic Reflexes in Type 1 Diabetes: Clinical Correlates

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

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