Key result
Type 1 diabetes in children is linked to a ~42% prevalence of cardiovascular autonomic dysfunction.
Why the study?
Cardiovascular autonomic dysfunction in children and adolescents with diabetes mellitus was not well characterized.
Is type 1 diabetes mellitus associated with cardiovascular autonomic dysfunction in children and adolescents?
Population
110 children and adolescents with type 1 diabetes and 130 non-diabetic controls
Comparison
Type 1 diabetes mellitus vs non-diabetic controls
Design
Case-control study
Authors
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May warrant autonomic screening in children with longer type 1 diabetes duration or poor control; leaves open reversibility and outcome impact.
Case-Control (n=240)
Is type 1 diabetes mellitus associated with cardiovascular autonomic dysfunction in children and adolescents?
Cardiovascular autonomic dysfunction is prevalent in children with type 1 diabetes and is independently predicted by longer disease duration and worse metabolic control.
Barkai et al. (1995) conducted a case-control in Type 1 diabetes mellitus (n=240). Type 1 diabetes mellitus vs. Non-diabetic controls was evaluated on Cardiovascular autonomic dysfunction (≥1 abnormal autonomic test). Type 1 diabetes in children was associated with a 42% prevalence of cardiovascular autonomic dysfunction, predicted by longer disease duration (OR 2.9) and worse metabolic control (OR 3.3).
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