What question did this study set out to answer?

To evaluate the prevalence and severity of cardiovascular autonomic nerve dysfunction in children and adolescents diagnosed with insulin-dependent diabetes mellitus.

December 1, 1995Journal of Paediatrics and Child Health

Autonomic neuropathy in diabetic children

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Why the study?

Is cardiovascular autonomic nerve dysfunction present in children and adolescents with insulin-dependent diabetes mellitus compared to healthy controls?

Key Points

To evaluate the prevalence and severity of cardiovascular autonomic nerve dysfunction in children and adolescents diagnosed with insulin-dependent diabetes mellitus.
Assessed 110 pediatric patients with diabetes (54 males, 56 females) and 100 age- and sex-matched healthy control subjects.
Conducted five standard cardiovascular reflex tests, evaluating heart rate and blood pressure responses to standing, deep breathing, the Valsalva manoeuvre, and sustained handgrip.
Autonomic dysfunction was identified in 47 of 110 diabetic patients (42.7%), with 22 categorized as early, 18 as definite, and 7 as severe.
Abnormal autonomic function showed no statistically significant correlation with sex, glycemic control, diabetes duration, retinopathy, or persistent microalbuminuria.
Heart rate variation during the Valsalva manoeuvre and the 30:15 standing ratio served as the most sensitive markers for identifying autonomic dysfunction.

Structured PICO

Is cardiovascular autonomic nerve dysfunction present in children and adolescents with insulin-dependent diabetes mellitus compared to healthy controls?

Population

110 children and adolescents with insulin-dependent diabetes mellitus (54 male, 56 female) and 100 healthy sex and age-matched children.

Comparator

100 healthy sex and age-matched children.

Outcome

Presence of cardiovascular autonomic nerve dysfunction assessed by standard cardiovascular reflex tests.surrogate

Cardiovascular autonomic nerve dysfunction can be present in asymptomatic children and adolescents with insulin-dependent diabetes mellitus, detectable by sensitive indices like heart rate variation during Valsalva manoeuvre.

Discussion

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Implication

Autonomic dysfunction may occur asymptomatically in diabetic youth; Level 4 data leave open prognostic value and screening utility.

Cite This Study

Verrotti et al. (1995) studied this question.

synapsesocial.com/papers/6a82beabba0d07321510ba36 https://doi.org/10.1111/j.1440-1754.1995.tb00881.x

Topics

Women and heart disease

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Autonomic neuropathy in diabetic children

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Autonomic neuropathy in diabetic children

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider