Key result
Children with type 1 diabetes after the remission phase had significantly higher mean resting heart rates compared to healthy controls (88.5 vs. 72.2 beats/min; p<0.01).
Why the study?
Do children with early-stage type 1 diabetes exhibit subclinical signs of autonomic neuropathy compared to healthy controls?
Population
54 children with type 1 diabetes and 30 healthy age-matched children.
Comparison
Type 1 diabetes (observational exposure) vs Healthy age-matched children
Design
Cross-sectional
Authors
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May indicate early subclinical autonomic neuropathy in pediatric T1D; hypothesis-generating for prospective screening studies.
Observational (n=84)
Do children with early-stage type 1 diabetes exhibit subclinical signs of autonomic neuropathy compared to healthy controls?
Absolute Event Rate: 88.5% vs 72.2%
p-value: p=<0.01
Initial functional disturbances of the autonomic nervous system appear early in the course of childhood type 1 diabetes, highlighting the need to screen for subclinical neuropathy.
L Kassay (2008) conducted an observational in Type 1 diabetes (n=84). Type 1 diabetes vs. Healthy age-matched children was evaluated on Mean resting heart rate (p=<0.01). Children with type 1 diabetes after the remission phase had significantly higher mean resting heart rates compared to healthy controls (88.5 vs. 72.2 beats/min; p<0.01).
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