Early Progression of the Autonomic Dysfunction Observed in Pediatric Type 1 Diabetes Mellitus
Why the study?
Do young patients with type 1 diabetes mellitus exhibit early and progressive cardiac and vascular autonomic dysfunction compared to healthy controls?
Population
93 young patients with type 1 diabetes mellitus under insulin treatment and 68 children of comparable age as…
Design
Cross-sectional
Follow-up
1 year
Authors
Discussion
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Member takes
Implication
Supports early autonomic dysfunction in pediatric type 1 diabetes; hypothesis-generating and requires longitudinal studies before clinical adoption.
Structured PICO
Do young patients with type 1 diabetes mellitus exhibit early and progressive cardiac and vascular autonomic dysfunction compared to healthy controls?
P
Population
93 young patients with type 1 diabetes mellitus under insulin treatment (subdivided into children: 11.5+/-0.4 years; adolescents: 19.3+/-0.2 years) and 68 children of comparable age as a reference group.
C
Comparator
68 children of comparable age serving as a reference group
O
Outcome
Time and frequency domain analysis of RR interval and systolic arterial pressure variability, gain of cardiac baroreflex, and sympathetic vasomotor controlsurrogate
Pediatric patients with type 1 diabetes mellitus demonstrate early and progressive signs of cardiac and vascular autonomic dysfunction, including reduced baroreflex gain and increased sympathetic vasomotor regulation.
Cite This Study
Lucini et al. (2009) studied this question.