Key result
Alteration of AMPK activity via genetic knockout, adenoviral expression, or pharmacological inhibition did not alter p38 MAPK activation during myocardial ischemia.
Population
Adult rat ventricular myocytes and isolated mouse hearts
Comparison
Alteration of AMPK activity via genetic… vs Wild-type models or models without AMPK…
Design
Preclinical
Authors
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p38 MAPK activation proceeds independently of AMPK during ischemia; leaves open relevance to human myocardium or therapeutic targeting.
Although both AMPK and p38 MAPK are activated during myocardial ischemia, p38 MAPK activation occurs independently of AMPK.
Jacquet et al. (2007) studied Myocardial ischemia. Alteration of AMPK activity vs. Basal conditions or wild-type was evaluated on p38 MAPK activation during myocardial ischemia. Alteration of AMPK activity via genetic knockout, adenoviral expression, or pharmacological inhibition did not alter p38 MAPK activation during myocardial ischemia.
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