Congenital heart disease impacts fetal brain development and increases the risk of in-utero and postnatal brain injury, necessitating standard pre- and postoperative neurodevelopmental evaluation.
Neurodevelopmental evaluation should be standard practice for CHD patients to identify impairments and optimize outcomes given the impact of CHD on fetal brain development.
PURPOSE OF REVIEW: Advances in cardiac surgical techniques and intensive care have led to improved survival in babies with congenital heart disease (CHD). Although it is true that the majority of children with CHD today survive, many have impaired neurodevelopmental outcome. Although continuing to improve short-term morbidity and mortality are important goals, recent research has focused on defining the impact of CHD on brain development and brain injury in utero. RECENT FINDINGS: The impact of CHD on the developing brain of the fetus and infant will be discussed. Neurologic abnormalities detectable prior to surgery will be described and postnatal progression of abnormalities will be highlighted. Potential causes of these findings will be discussed, including altered cerebral blood flow in utero, and brain development and risk for in-utero and postnatal brain injury. Finally, neurologic and developmental outcome after surgical repair of CHD will be reviewed. SUMMARY: Neurodevelopmental evaluation preoperatively and postoperatively in CHD patients should be standard practice, not only to identify those with impairments who would benefit from intervention services but also to identify risk factors and strategies to optimize outcome. Fetal management and intervention strategies for specific defects may ultimately play a role in improving in-utero hemodynamics and increasing cerebral oxygen delivery to enhance brain development.
Donofrio et al. (Sat,) conducted a review in Congenital heart disease (CHD). Congenital heart disease was evaluated on Fetal brain development and brain injury. Congenital heart disease impacts fetal brain development and increases the risk of in-utero and postnatal brain injury, necessitating standard pre- and postoperative neurodevelopmental evaluation.