Key result
Female sex was associated with 53-75% higher basal and maximal insulin-stimulated glucose transport per cell in human subcutaneous abdominal adipocytes compared to males (P<0.01).
Why the study?
Is there a sex difference in basal and maximum insulin-stimulated glucose transport in rat and human adipocytes?
Population
Adipocytes isolated from abdominal subcutaneous fat tissue of 19 human subjects with varying degrees of…
Comparison
8 nM insulin vs Absence of insulin and comparison between male…
Design
Preclinical
Authors
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Requires validation before sex-specific metabolic care; leaves open translation to systemic insulin sensitivity.
Observational (n=19)
Is there a sex difference in basal and maximum insulin-stimulated glucose transport in rat and human adipocytes?
Effect estimate: 53-75% higher
p-value: p=<0.01
Basal and maximum insulin-stimulated glucose transport is significantly higher in adipocytes isolated from females compared to males, independent of adipose cell size and species.
Foley et al. (1984) conducted an observational in Varying degrees of obesity (n=19). Female sex vs. Male sex was evaluated on Basal and maximal insulin-stimulated glucose transport per cell (53-75% higher, p=<0.01). Female sex was associated with 53-75% higher basal and maximal insulin-stimulated glucose transport per cell in human subcutaneous abdominal adipocytes compared to males (P<0.01).
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